Our History
A Technical Advance Which Has Kept Pace With Regulations
Since initial experiments with video in the 1990s, ZeroFrame has kept pace with, and often pre-empted, regulatory developments in the pharmaceutical field. Every technical development has been an advance in terms of more effective, legible documentation usable in audits and inspections. Today we work with proprietary technology, dedicated teams and know-how developed on complex systems and machines throughout Europe.
1992
Early Developments
Luca Busi shot the first video footage in controlled environments with manual vials and stage lighting.
2002
The First Creative Solutions
Introduction of contrasting backgrounds to improve smoke visibility.
2007
Regulatory References
Publication of the first Annex 1: smoke tests become part of European guidelines (EU-GMP).
2014
Evolution of Smoke Traces
Adoption of WFI water-based foggers, which are more suitable for sterile environments than oil-based ones.
2015
More Sets of Eyes
Introduction of a multicamera system (four video cameras) with synchronised recording.
2017
Advanced Support
Addition of technical graphics in support of the framing and positioning of the smoke traces.
2019
Growth in the Field
Establishment of multiple teams working in parallel.
2020
Editing Department
Creation of a dedicated post-production team for visual optimisation of the footage.
2022
New Requirements
Revision of Annex 1: the guidelines explicitly require airflow visualisation studies to demonstrate the correct design and approval of systems, differential pressures and operating conditions.
2023
Dedicated Set-Ups
Development of new solutions for the precise positioning of cameras and foggers.
2024
Targeted Engineering
Design of personalised nozzles to reduce the impact on the air flows.